What those with a lot of money are doing: transfers to and from exchanges, exchange reserves, whales off exchanges, ETF flows, CME positions, the Coinbase premium, rates and money printing. The data arrives with different delays — on-chain is block time, ETFs publish after the US close, the CME report comes out on Friday about Tuesday — so the blocks are never added together.
Three rules: a transfer to an exchange is not a sale; an ETF inflow is not necessarily a purchase; wallets we do not know are called unknown.